Discussing Breast Cancer

It’s making news headlines — The FDA’s Oncologic Drugs Advisory Committee just approved the drug by biotech powerhouse Genentech for use in conjunction with chemotherapy to treat metastatic breast cancer.

Research has shown that use of the drug in combination with paclitaxel (Taxol) chemotherapy resulted in a 52 percent reduction in the risk of disease progression or death compared to those treated with paclitaxel alone — a doubling in progression-free survival.

From the Genentech press release: “There is no cure for metastatic breast cancer so it is important to control the disease as early and for as long as possible,” said Kathy Miller, M.D., Associate Professor of Medical Oncology, Indiana University School of Medicine and lead investigator on the E2100 trial. “Now with Avastin plus paclitaxel, we can increase the time a woman’s cancer is kept under control, and offer a biologic option to women who previously were limited to chemotherapies alone.”

Without boring you with the specifics of how it works, I’ll share this: Avastin works by cutting off the blood supply to the tumors. That’s one way to kill those suckers — at long last.

Meanwhile, the toxic side effects of high blood pressure and well, death, were considered by some to be too problematic and perhaps should have deterred the FDA and inhibited their decision. But let me ask you this … if you have metastatic disease, aren’t you willing to take a risk to improve your chances of survival? Aren’t you facing death head on and deserving of anything that might help you void that apparently imminent collision? Isn’t this approval going to bring us one step closer to a cure for these people that need one the most?

Imagine you have a headache … but you couldn’t take Tylenol because it was never approved since you’d be at risk of contracting a headache if you take it. That’s hypothetical and I have no idea if headaches are a side effects of Tylenol — but I hope you get my point. The fact that metastatic patients are at risk of losing their lives every day seems to outweigh every other risk of fatality, I think.

Bravo to the FDA. Bravo to Genentech — this is right along with your mission to develop drugs to address significant unmet medical needs and you know patients with metastatic breast cancer have unmet needs!

More importantly, bravo to all of you out there with metastatic disease that might benefit from this new treatment option. Bring it on!

Wednesday is the day … my first stint as a co-host on the Internet Radio Show Inspire!, sponsored by Breast Cancer Wellness magazine. Here’s the scoop on tomorrow’s guest:

Diagnosed with stage IV breast cancer at age 26, Heather Jose chose to fight the cancer head on by putting together a plan to battle cancer on a daily basis. Eight years later, Heather is healthy and using her experiences to speak to health care providers and patients about how much their actions and words can impact healing success. Heather is the author of “Letters to Sydney: Every Day I Am Killing Cancer” and a contributing writer for The Breast Cancer Wellness Magazine. Her husband Larry is a high school coach and they have two children, Sydney and Ty.

To listen to my conversation with Heather on Inspire! Wednesday, October 10th, at 12:00 NOON CST, just click here!

Elizabeth Prostic (Lizzie) was diagnosed with stage IV breast cancer in October 2004. She was just 31 years old and a first time mom to a three-month-old baby at the time. She was one of Allison Winn Scotch’s closest friends.

Six months after her diagnosis, Lizzie passed away. Allison still grieves, still mourns … and yes, Lizzie was her inspiration as she started writing The Department of Lost & Found. But all those who’ve battled breast cancer inspire her, not just her friend.

Here’s something Allison said about survivors in a recent interview: “I’ve always walked away with the impression that these women are incredible and that their courage is unmatchable.”

Interestingly, Allison’s fictional character, Natalie, barely resembles Allison’s friend, Lizzie. However, Allison still viewed the book as an opportunity to rewrite her friend’s story: “Not her story in particular, but that of a woman who had so much left to live for. Only this time I could control the ending, rather than watch helplessly from the sidelines.”

Ah, to control the ending. Unfortunately, unless we’re talking about writing a story of our own, we just can’t do that now, can we? We don’t know the cards we’ll be dealt. We just have to make the best of the hand we get.

Allison herself said, “I really believe that life is what you do with it, something Natalie learns along her bumpy road as well. Losing Lizzie only heightened those feelings. The simple, and perhaps cliched, truth is that you only get one shot, and who knows when, how or why that might be stripped away from you.”

As I said yesterday when I reviewed The Department of Lost & Found, Lizzie would be proud of her friend, Allison.

She’d also be proud of her husband, Michael Lundblad, and her parents. Together, they established a foundation in her honor called The MetaCancer Foundation (www.metacancer.org) to provide inspiration and psychosocial support for patients and caregivers living with metastatic cancers.

It’s a great site. If you get a chance, check it out. Meanwhile, in case you don’t, tomorrow I’ll post about the red shoes.

Red shoes, you ask? Red shoes?

Ha, ha … you’ll have to wait and see!